Beatriz Matos Castaño and Alberto Martínez Castillo formed the professional practice Matos Castillo Arquitectos in 1985. Both linked to teaching, Beatriz, Doctor of Architecture with the thesis "Eduardo Chillida, Architect", has been a professor of projects at the European University of Madrid UEM (1997-2021) and the ETSAM, UPM, (1989-2003); Alberto, Doctor of Architecture with the thesis "Max Bill: Variaciones sobre la búsqueda de la belleza", is full professor of projects at the ETSAM, UPM, (1987-2023) and was a professor at the CEU Architecture (2000-2001) and the UEM (2010-2020). They have also been guest lecturers at various schools of architecture; University of Navarra, University of the Basque Country (UPV/EHU), Polytechnic University of Valencia (ETSAV), Ricardo Palma University (Lima, Peru), University of Alcalá de Henares, Institut for Architectur und Raumplanung (Liechtenstein)...

From the outset, they have begun professional work based fundamentally on architectural competitions as a way of combining research and design practice. They regularly participate in round tables, workshops, summer courses, conferences, and exhibitions, and have been part of multiple juries of competitions. They have also organised several cycles of conferences and exhibitions as curators.

His work has been widely published in national and international books and magazines. Their built work includes the Garay industrial building, the Casino de la Reina Park and Day Centre in Madrid, the police stations in Albacete and Logroño, the unfinished Goya Fuendetodos engraving museum and, more recently, the refurbishment of the Boadilla Library. Dedicated for years to housing research, they have built several VPO buildings as a result of competition prizes.  They are currently working on the construction of the Faculty of Medicine in Badajoz and the refurbishment of the Salesas Convent in Pamplona. They have received more than fifty prizes in architectural competitions, as well as numerous awards and recognitions for their built work. Among the latter: the Andrea Palladio International Prize 1993 (IV edition Vicenza, Italy), the II Muestra de Arquitectos Jóvenes Españoles Prize 1992, several Architecture Prizes Madrid City Council (1998, 2001, 2003), Quality Prizes Madrid Community (2000, 2003, 2005), COAM Prizes (2000, 2005, 2021) and they have been finalists twice (1999, 2004) in the FAD prizes.